| Extension | File Type | Files scanned | Contributor |
| Z | InstallShield archive | 6 | Surfer |
| Z | UNIX Compressed file | 3 | |
| Z/GZ/GZIP | GZipped File | 167 | Davide "Airex" Airaghi |
| Z3D | ZModeler 3D Model | 28 | |
| Z5 | Z-Code V5 adventure for Infocom Z-Machine | 67 | |
| Z8 | Z-Code V8 adventure for Infocom Z-Machine | 4 | |
| ZABW | AbiWord compressed document | 3 | |
| ZAP | ZoneLabs Zone Alarm data | 18 | |
| ZCFG | HLGuard Z config file | 3 | |
| ZDP | Avery DesignPro Label design | 89 | |
| ZDX | Avery Design clipart index | 3 | |
| ZED | ZX-Edit document block | 3 | |
| ZEXP | Zope binary export file | 16 | |
| ZFX | ZipForm data | 20 | |
| ZGEPROJ | ZGameEditor project | 9 | |
| ZGT | Oren-made scientific document | 3 | |
| ZIP | Apple Mac OS X Dashboard Widget | 11 | |
| ZIP | Aston Shell theme | 11 | |
| ZIP | Opera Widget | 11 | |
| ZIP | Pivot Style Template | 10 | |
| ZIP | Rockbox Theme package | 9 | |
| ZIP | Simple Machines Forums theme | 38 | |
| ZIP | SubEthaEdit Mode | 45 | |
| ZIP | Trillian zipped Skin | 19 | |
| ZIP | Virtual Skipper skin | 17 | |
| ZIP | ZIP compressed archive | 20 | |
| ZIP | ZIP compressed archive (empty) | 7 | |
| ZIP | ZIP compressed archive (multivolume) | 33 | |
| ZIP | ZLock Pro encrypted ZIP | 5 | |
| ZIR | Compass and Ruler geometry | 9 | |
| ZIX | WinZix compressed archive | 2 | |
| ZJS | Zenographics ZjStream Page Description Language (big-endian) | 2 | |
| ZJS | Zenographics ZjStream Page Description Language (little-endian) | 2 | |
| ZL | Easy CD Creator Drag to Disk File | 4 | |
| ZMF | Zoner Draw | 3 | |
| ZMF | Zoner Draw (container with preview) | 3 | |
| ZMG | Novell ZENworks Desktop Management image | 3 | |
| ZMI | ZAP Meta Image | 11 | |
| ZMV | ZSNES movie capture | 2 | |
| ZNO | Zinio Reader Magazine | 6 | |
| ZOO | Microsoft Zoo Tycoon saved game | 8 | Dinoguy1000 |
| ZOO | ZOO compressed archive | 4 | |
| ZOT | Zoot information processor database | 4 | |
| ZSG | Zillions of Games Solution - Saved Game | 29 | |
| ZST | ZSNES Save State | 4 | |
| ZTH | DivX Connected Theme | 14 | |
| ZUML | Poseidon for UML project file | 10 | |
| ZVD/ZYX | ZyXEL Voice Format audio | 12 | |
| ZVPL | Visual Paradigm License Key | 4 | |
| ZVR | Recorded voice audio | 4 | |
| ZVR | ZVR eBook | 2 | |
| ZWS | ZiLOG Developer Studio Workspace file | 3 | |
| ZX82 | Speculator '97 snapshot | 11 | |
| ZXS | zx32's ZXS snapshot format | 17 | |
| ZZ | Zzip compressed archive | 6 | |
| ZZT | ZZT Game Creation System game | 16 | |
